I like how the veteran health journalist Andrew Holtz once explained the interesting concept of surrogate or intermediate endpoints for us dull-witted patients. He cites, for example, studies on patients with diabetes that included aggressive control of blood sugar, high blood pressure and cholesterol in people considered to be at very high risk for heart attacks. But oddly enough, this research showed that:
- strict management of blood sugar did not reduce heart attack deaths
- reduction in high blood pressure levels did not reduce heart attack deaths
- controlling high LDL cholesterol numbers with the use of statin drugs did not reduce heart attack deaths
Holtz explains that lab results may not actually be accurate predictors of mortality – they are merely intermediate or surrogate endpoints along the way.
And just because a drug improves lab test results doesn’t mean it saves lives – despite the efforts of Big Pharma to convince drug prescribers otherwise. Continue reading