Avandia: a very short history of a very bad drug

The drug giant GlaxoSmithKline’s controversial diabetes drug Avandia (generic name rosiglitazone) works by helping diabetics balance their blood-sugar levels. But since its inception, it has been found to increase the risk of heart attacks and strokes — and even death.

As many as 100,000 heart attacks, strokes, deaths and cases of heart failure may be directly attributed to Avandia since the drug was launched in 1999, according to FDA scientist Dr. David Graham.  Yet physicians are still prescribing the drug to nearly half a million people, which translates into approximately $900 million in annual sales for GSK.  How has this been allowed to happen? Let’s take a look at the history of this potentially lethal but still-legal drug, courtesy of PBS: Continue reading

If only Avandia were more like Toyota

Poor Toyota.  The car maker has been forced to recall more than 8 million vehicles worldwide after news that at least 34 deaths have been linked to Toyota vehicle problems going back as far as 2004. But compare those 34 deaths with the more than 1,000 reports of patient deaths linked with the prescription drug Avandia in just one nine-month period last year, a death rate described by an Institute for Safe Medication Practices report as: “more than any other drug we monitor.” John Mack, editor of Pharma Marketing News, warns:

“If people are afraid to buy Toyotas, then based on average yearly death rates, they should be about 400 times more afraid to take Avandia.”   Continue reading