When you use bad science to sell drugs

Whenever I feel like I don’t have quite enough aggravation in my life, I like checking out Stuart Laidlaw’s medical ethics column in the Toronto Star. For example, Stuart’s eagle eye recently spotted a disturbing article about ‘marketing-based medicine’ published in the Journal of Bioethical Inquiry. It looked at the ever-so-slightly sleazy topic of data fishing.  It’s what Big Pharma does when science is used improperly to help market their drugs.  This includes selective use of clinical trial results to suppress or spin negative results.  For the sake of clarity, let’s call this “lying”.

Another example of marketing-based medicine is the alarmingly dangerous practice of medical ghostwriting. This happens when a report that’s bought and paid for by the drug company to give a positive review of one of its products is then published in medical journals under the name of a respected academic who had little (if anything) to do with the actual journal article.  See also: Partners in Slime: Why You Should Be Alarmed About Medical Ghostwriting. Continue reading

How are hockey-playing goons the same as “puzzled” medical journal editors?

hockey calgary fightI’ve often said to my hockey-mad son Ben that we could end on-ice fighting in hockey (not, incidentally, our national sport, but arguably our Canadian obsession) if only the National Hockey League would put me in charge for just one week. But the folks who do run the NHL clearly have no appetite for banning hockey fighting, or they would have acted to end it by now.

Despite their feeble protests about the unacceptability of fighting and the known dangers of career-ending concussions, team owners tolerate cheap shots by beefy goons who spear, hit, and drop their gloves to fight. The League accepts it, the owners accept it, the players accept it, and the fans apparently love it.

There is, alas, no organizational will to ban violence on the ice.

And much like hockey goons, medical journal editors could end the appallingly unethical and dangerous practice of medical ghostwriting in one week, but these editors clearly have no appetite for banning ghostwriting in their journals, or they would have acted to end it by now.

There is, alas, no organizational will to ban medical ghostwriting. Continue reading

All bark, no bite: new Big Pharma trials/ghostwriting guidelines

pills purple mixLet’s not pop the champagne corks just yet to celebrate the recent announcement of new guidelines for Big Pharma from the trade group Pharmaceutical Research & Manufacturers of America (PhRMA).  The wordy guidelines are called Principles on Conduct of Clinical Trials and Communication of Clinical Trial Results. They went into effect last week, and are a response to mounting scandals and scrutiny about how clinical research trials are conducted and reported. These new principles also cover issues like authorship contributions and medical ghostwriting; disclosure of financial conflicts of interest; public registration of clinical trials; and publicly accessible summaries of all clinical trial results.

These last two are apparently a stab at addressing the current reality that negative clinical trial results either never see the light of day or are only selectively reported to favour the drugs being tested. The principles have been hailed by some as a step in the right direction, although many point out that they may have more bark than bite in addressing, for example, the chronic problem of medical ghostwriting. Continue reading

Merck paying off 3,100 families for heart attack/stroke deaths linked to Vioxx painkilling drug

vioxx blueDrug giant Merck & Co. is paying the families of more than 3,100 Vioxx painkiller users who died of heart attacks and strokes that were blamed on the drug. Merck introduced Vioxx in 1999 but withdrew it from the market in 2004 when a study showed the drug doubled the risk of heart attacks and strokes. By 2007, Merck had set up a fund of $4.85 billion (yes, that’s billion with a ‘B’)  to cover claims of death and lesser injuries, after reserving $1.9 billion to fight over 26,600 Vioxx lawsuits in court. Houston attorney Mark Lanier observed at the time:

“We don’t know any drug right now with this number of deaths associated with it. This is a very sad chapter in the tragedy of pharmaceutical companies gone wild.” 

And – quelle surprise! - Vioxx turns out to be one of countless prescription drugs that have been fraudulently promoted in industry-funded ghostwritten articles in medical journals.    Continue reading